Results 41 to 50 of about 19,209 (252)

THE FIRST CASE OF HUMAN GENOME EDITING: CRIMINAL LAW PERSPECTIVE

open access: yesBRICS Law Journal, 2019
This article analyzes the legal assessment of the human genome modification experiment at the pre-implantation stage conducted by a group of scientists headed by He Jiankui, professor at the Southern University of Science and Technology (SUSTech) in ...
D. Sergeev
doaj   +1 more source

L'unité du droit international public est-elle aujourd'hui en danger ?

open access: yes, 2003
Guillaume Gilbert. L'unité du droit international public est-elle aujourd'hui en danger ?. In: Revue internationale de droit comparé. Vol. 55 N°1, Janvier-mars 2003. pp.
Guillaume, Gilbert
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tendency Towards Psychologization in Assessing Public Danger

open access: yesПсихология и право
The article reflects the results of a study of controversial issues of assessing public danger. Conclusions are drawn about the current trend towards psychologization in the assessment of social danger, both in law enforcement practice and in ...
V.A. Ilyina
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Public health and genetics—a dangerous combination? [PDF]

open access: yesEuropean Journal of Public Health, 2005
‘It is clear, that the science of genomics holds tremendous potential for improving health globally… The specific challenge is how to harness this knowledge and have it contribute to health equity, especially among developing nations…’ This is a quote by Gro Harlem Brundtland, former Director General of WHO, which can be found in the year 2000 Report ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Administrative prejudice and the principle of Non bis in idem

open access: yesRUDN Journal of Law
The concept of administrative prejudice, which enables the imposition of criminal liability for repeated commission of an administrative offense, has been the subject of sustained scrutiny among scholars.
Willie A. Maslov
doaj   +1 more source

Qualification of Acts in the Context of Insignificance: Theoretical and Practical Issues

open access: yesСибирское юридическое обозрение, 2016
The article deals with the qualification of insignificance of act problematic issues, the impact of judicial discretion in the formation of judicial practice on the assessment of insignificance is reflected.
Irina G. Ragozina   +1 more
doaj   +1 more source

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