Results 151 to 160 of about 570,744 (306)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Quality of public finances and growth [PDF]

In this paper we review the linkages between the quality of public finances, that is, the level and composition of public expenditure and its financing via revenue and deficits, and economic growth.
Afonso, António, Ebert, Werner, Schuknecht, Ludger, Thöne, Michael   +3 more
core  

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source

Slow Progress Under Brazil's Native Vegetation Protection Law in the Southeastern Amazon. [PDF]

Environ Manage
Almada HK, Cavalcante RBL, Walfir Souza-Filho PM, Nascimento W, Nunes S.   +4 more
europepmc   +1 more source

"The "Keynesian Moment" in Policymaking, the Perils Ahead, and a Flow-of-funds Interpretation of Fiscal Policy" [PDF]

With the global crisis, the policy stance around the world has been shaken by massive government and central bank efforts to prevent the meltdown of markets, banks, and the economy. Fiscal packages, in varied sizes, have been adopted throughout the world
Andrea Terzi
core  

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Preparedness deserts: a framework for understanding and addressing geographic inequities in bystander response to out-of-hospital cardiac arrest. [PDF]

Resusc Plus
Riley GV, Faizaan MZ, Katoch C, Cozzi N.
europepmc   +1 more source

Public Sector Deficits and Macroeconomic Performance in Lebanon: A Simulation Analysis [PDF]

The main aims of this paper are as follows. First, to macro model prospective development in the Lebanese economy for policy analysis and evaluation. This study develops s a dynamic macroeconomic model for Lebanon including the budget deficit and the ...
Saleh, Ali Salman
core  

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

Post-acute sequelae after Nipah virus infection: a systematic review and meta-analysis. [PDF]

EClinicalMedicine
Zhang T, Wei Q, Schmit N.
europepmc   +1 more source