Results 121 to 130 of about 17,310 (256)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Public deliberation to assess patient views on biosimilar medication switching for the treatment of inflammatory bowel disease. [PDF]

BMC Health Serv Res
Ryan KA, Cohen-Mekelburg S, Baker JA, Weinheimer-Haus EM, Krenz C, Hou JK, De Vries R, Waljee AK.   +7 more
europepmc   +1 more source

Effect of Public Deliberation on Patient Attitudes Regarding Consent and Data Use in a Learning Health Care System for Oncology. [PDF]

J Clin Oncol, 2019
Jagsi R, Griffith KA, Jones RD, Krenz C, Gornick M, Spence R, De Vries R, Hawley ST, Zon R, Bolte S, Sadeghi N, Schilsky RL, Bradbury AR.   +12 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

A 4-Site Public Deliberation Project on the Acceptability of Youth Self-Consent in Biomedical HIV Prevention Trials: Assessment of Facilitator Fidelity to Key Principles. [PDF]

JMIR Form Res
Draucker CB, Carrión A, Ott MA, Hicks AI, Knopf A.   +4 more
europepmc   +1 more source

Brookings supports breastfeeding: using public deliberation as a community-engaged approach to dissemination of research. [PDF]

Transl Behav Med, 2017
Anderson J, Kuehl RA, Mehltretter Drury SA, Tschetter L, Schwaegerl M, Yoder J, Gullickson H, Lamp J, Bachman C, Hildreth M.   +9 more
europepmc   +1 more source

Globalisation, legitimacy and public deliberation

Most significant policy issues facing humanity reach across national borders. Consequential political decisions with cross-national effects are frequently made by states, non-state organisations, and corporations. Under these circumstances, it is widely acknowledged that it is important to conduct public deliberation at the global level.
openaire   +2 more sources

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Public Deliberation for Ethically Complex Policies: The Case of Medical Assistance in Dying in Canada. [PDF]

Healthc Policy
Dhamanaskar R, Abelson J.
europepmc   +1 more source