Results 41 to 50 of about 20,588,972 (265)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Stroke Risk Factor Awareness Among Populations in Saudi Arabia
International Journal of General Medicine, 2021 Reem Bakraa,1 Ruba Aldhaheri,1 Mada Barashid,1 Sarah Benafeef,1 Maram Alzahrani,1 Rasha Bajaba,2 Samah Alshehri,3 Mohannad Alshibani3 1College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Laboratory and Blood Bank Department, King Fahd ...
Bakraa R +7 more
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
HIGHER EDUCATION FUNDING: COMPARATIVE ANALYSIS OF PORTUGAL AND POLAND PUBLIC SYSTEMS
Copernican Journal of Finance & Accounting, 2017 In Europe governments remain a primary funding source for higher education institutions. In this context, reflections on higher education funding models have been discussing since knowledge has been increasingly perceived as an essential condition for
Danuta Dziawgo +2 more
doaj
Millet Mekteplerinin Halk Eğitimi Açısından İncelenmesi
Yakın Dönem Türkiye Araştırmaları, 2020 Türkiye’de 1928 yılında Arap harflerinden oluşan alfabe terk edilerek Latin harflerine dayanan yeni bir alfabe kabul edildi. Bu inkılap sonrası yeni alfabenin halka öğretilmesi amacıyla Millet Mektepleri kuruldu.
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doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Exploring shared leadership in public organizations: evidence from the educational arena
Revista de Administração Pública, 2020 Collective leadership, reflecting the representative and participatory character of bureaucracies, is known to have a good fit for public organizations.
Juliana Carvalho +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source