Results 51 to 60 of about 20,588,972 (265)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Cadernos de Pesquisa, 2012 Este trabalho tem por objetivo interpretar o tema da educação em alguns escritos de Rousseau. À luz da bibliografia sobre o tema, a análise centra-se no modo pelo qual Rousseau compreende a educação especialmente no Projeto para a educação do Senhor de ...
Carlota Boto
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2019 A photocopy of a pamphlet published in 1851 entitled "Rules and Regulations of the Board of Education for the Government of the Public Schools of Toledo, Ohio".
Board of Education, Toledo, Ohio
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Domestic Science For Elementary Grades
, 2019 Lessons in domestic science for seventh and eighth grade students. Includes lessons in preparing food, baking, and clean up.
Toledo (Ohio). Board of Education
core
Social SciencesThis exploratory study examines the experiences of public elementary school educators to understand the shifting educational priorities and renegotiation of borders between home and school during and since the COVID-19 pandemic.
Rachel Glickman, Kristin Labs
doaj +1 more source
HEALTH EDUCATION AND PUBLICITY [PDF]
American Journal of Public Health, 1923 The Clinic on Printed Matter held at Cleveland in October had so many applicants for examination that only a small percentage of them could be accepted. As it was, the number of dodgers, leaflets, pamphlets, booklets, and posters admitted to the clinic was greater than the examining specialists could handle satisfactorily.
openaire +36 more sources