Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Prediction of cardiovascular risk using machine-learning methods. Sex-specific differences
Frontiers in Cardiovascular MedicineBackgroundMachine learning (ML) algorithms offer some advantages over traditional scoring systems to assess the influence of cardiovascular risk factors (CVRFs) on the risk of major cardiovascular event (MACE), and could be useful in clinical practice ...
Sara Castel-Feced +19 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Engaging primary care professionals in OECD’s international PaRIS survey: a documentary analysis
Health Research Policy and SystemsHealthcare professionals have first-hand experience with patients in clinical practice and the dynamics in the healthcare system, which can be of great value in the design, implementation, data analysis and dissemination of research study results ...
Candan Kendir +7 more
doaj +1 more source
State of New York Public Employment Relations Board Decisions from November 7, 1975 [PDF]
, 1974 11_7_1975_PERB_BD_DecisionsOCR.pdf: 107 downloads, before Oct.
New York State Public Employment Relations Board
core +6 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
State of New York Public Employment Relations Board Decisions from April 29, 1974 [PDF]
, 1974 4_29_1974_PERB_BD_DecisionsOCR.pdf: 137 downloads, before Oct.
New York State Public Employment Relations Board
core +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
State of New York Public Employment Relations Board Decisions from May 27, 2011 [PDF]
, 2011 BD_Mtng_5_27_2011.pdf: 547 downloads, before Oct.
New York State Public Employment Relations Board
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source