Results 121 to 130 of about 11,703,772 (300)
Effects of post-activation performance enhancement on tennis serve velocity and accuracy
Scientific ReportsThis study systematically compared the effects of different activation sites and modes on serve velocity (SV) and serve accuracy (SA) across multiple time windows to clarify the time course and practical significance of post-activation performance ...
Wenlai Cui +3 more
doaj +1 more source
Advanced Science, EarlyView.A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu +7 more
wiley +1 more source
Do States Free Ride in Antitrust Enforcement? [PDF]
Recent research has documented a substantial role in antitrust enforcement by U.S. states. While many of the cases litigated involve small local firms, a non-trivial portion encompass multiplestate issues.
Robert M. Feinberg, Thomas A. Husted
core
Cognitive decision-making in police use of force: a scoping review based on eye-tracking research
Frontiers in PsychologyPurposeThis scoping review aimed to systematically map and synthesize the existing eye-tracking literature on cognitive decision-making in police use of force.
Yaoguang Li, Wenlai Cui
doaj +1 more source
Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
Advanced Science, EarlyView.In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang +14 more
wiley +1 more source
Advanced Science, EarlyView.A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang +6 more
wiley +1 more source
Investigating Discretionary Environmental Enforcement: a pilot experiment [PDF]
In this work, we conducted a laboratory experiment in order to test the findings of a theoretical environmental enforcement model played as a strategic game where the firm’s behavior is influenced by the course of actions discretionally undertaken by ...
Morone, Piergiuseppe +2 more
core
Advanced Science, EarlyView.DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li +17 more
wiley +1 more source
Evaluating drug law enforcement interventions directed towards methamphetamine in Australia [PDF]
, 2012 This report presents a preliminary analysis comparing the costs and impacts different types of law enforcement have on methamphetamine use. Methamphetamine belongs in the class of stimulant drugs referred to as Amphetamine Type Stimulants (ATS).
David Bright, Wendy Gong
core
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source