Results 71 to 80 of about 5,761,819 (344)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
From measures to meaning: a case study on co-defining aphasia recovery outcomes with patient experts
Research Involvement and EngagementBackground People with post-stroke aphasia are often excluded from shaping the research meant to support their recovery. Communication barriers, research norms, and traditional outcome frameworks contribute to a lack of meaningful involvement ...
Ann Blair Kennedy +9 more
doaj +1 more source
Cambridge Prisms: Global Mental HealthCommon mental disorders (CMDs) are a leading cause of burden and disability globally. Approximately 75% of those living with CMDs reside in low- and middle-income countries (LMICs), and up to 90% of those needing mental health care do not receive it. The
John Patena +14 more
doaj +1 more source
Panel Session toward Improved Communication and Engagement with the Public after the Fukushima Daiichi Nuclear Power Plant Accident: Study Reports and Discussion with Specialists from Relevant Fields [PDF]
, 2021 Hiroko Yoshida +4 more
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Scientific ReportsPassive acoustic monitoring has become a widely used method to study cetaceans, especially for populations facing escalating threats from noisy human activities, including shipping traffic, fishing industry and marine constructions.
Sara Ferri +7 more
doaj +1 more source
Patient and Public Engagement in Integrated Knowledge Translation Research: Are we there yet?
Research Involvement and Engagement, 2019 Plain English summaryThere have been many attempts to improve how healthcare services are developed and delivered. Despite this, we know that there are many gaps and differences in practice and that these can lead to poor patient outcomes.
D. Banner +6 more
semanticscholar +1 more source
Mechanisms for enhancing public engagement with citizen science results
People and Nature, 2020 1. Citizen science is frequently cited as a successful approach for increasing pub lic engagement with environmental issues, but this requires a purposeful design that is inclusive of, and responsive to, diverse interests.
Catriona J. MacLeod, K. Scott
semanticscholar +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Health Expectations, 2018 Patient and public engagement is growing, but evaluative efforts remain limited. Reviews looking at evaluation tools for patient engagement in individual decision making do exist, but no similar articles in research and health systems have been published.
A. Boivin +6 more
semanticscholar +1 more source