Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
GOVERNMENT EXPENDITURES IN CHINA AND TAIWAN: DO THEY FOLLOW WAGNER¡¯S LAW? [PDF]
This paper tests Wagner¡¯s Law for China and Taiwan, using annual time series data covering the period 1979-2002. To estimate the long-run relationship between government expenditures and output, we use a robust estimation method known as the Bounds Test
Chiung-Ju Huang
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Availability and Access to Orphan Drugs for Rare Cancers in Bulgaria: Analysis of Delays and Public Expenditures. [PDF]
Cancers (Basel)Kostadinov K +5 more
europepmc +1 more source
Expenditure Rules: Limiting the Level or the Variation of Public Expenditure?
EconomiesThe main goal of the first-generation expenditure rules was to ensure fiscal discipline: preserving a sound fiscal framework and public debt sustainability. Regarding this goal, analytically as well as empirically, limiting the share of public expenditure in GDP would be more appropriate in case of weak potential economic growth or if the public ...
openaire +3 more sources
Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction
Advanced Science, EarlyView.We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen +3 more
wiley +1 more source
Efficient Direct Recycling of Spent Batteries: Integrated Lithiation and Delamination
Advanced Science, EarlyView.An integrated process for the delamination and relithiation of spent cathodes, LixNi0.6Co0.2Mn0.2O2 and LixFePO4, under open‐air conditions is proposed. The transition‐metal (Ni) oxidation state in the cathode is reduced by the oxidation of diethylene glycol, facilitating relithiation. Glycol aldehyde formation induces 100% electrode delamination.
Jeonghwan Song +11 more
wiley +1 more source
The combined incidence of taxes and public expenditures in the Philippines [PDF]
Incidence studies of fiscal policy in developing countries typically examine either the distribution of tax burdens or the incidence of public expenditures. But the central issue for policymakers is the combined or net incidence of fiscal activities. One
Devarajan, Shantayanan +1 more
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Hearing loss and healthcare expenditures in the United States: evidence of a public health market failure. [PDF]
Front Public HealthArbel Y, Arbel Y, Kerner N, Kerner O.
europepmc +1 more source
Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design
Advanced Science, EarlyView.A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram +4 more
wiley +1 more source
Tax Expenditures, the Size and Efficiency of Government, and Implications for Budget Reform [PDF]
One possible explanation for the difficulty in controlling the budget is that a major component of spending —tax expenditures—receives privileged status. It is treated as tax cuts rather than spending.
Marvin Phaup, Leonard E. Burman
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