Results 51 to 60 of about 2,014,174 (305)

Empowering Small Donors in Federal Elections [PDF]

, 2012
An effective new public matching funds system in which citizens direct the distribution of public funds to candidates would fundamentally change the way our campaigns are financed.
Adam Skaggs, Fred Wertheimer
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Public hedge funds

Journal of Financial Economics, 2019
Abstract Hedge funds managed by listed firms significantly under-perform funds managed by unlisted firms. The under-performance is more severe for funds with low manager deltas, poor governance, and no manager co-investment, or those managed by firms whose prices are sensitive to earnings news.
SUN, Lin, TEO, Song Wee Melvyn
openaire   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Implementation of preconception care for preventing adverse pregnancy outcomes in rural and tribal areas of Nashik District, India

Preventive Medicine Reports
Introduction: The World Health Organization has suggested preconception care to improve pregnancy outcomes. Hence, the study aimed to compare the effect of preconception care on pregnancy outcomes, particularly prematurity and low birth weight.
Prakash Prabhakarrao Doke, Amruta Paresh Chutke, Sonali Hemant Palkar, Jayashree Sachin Gothankar, Prasad Dnyandeo Pore, Archana Vasantrao Patil, Aniruddha Vinayakrao Deshpande, Khanindra Kumar Bhuyan, Madhusudan Vaman Karnataki, Aparna Nishikant Shrotri, Ravindra Gopal Chaudhari, Mohan Sitaram Bacchav, Motilal Bajirao Patil, Rupeshkumar Balasaheb Deshmukh   +13 more
doaj   +1 more source

Public funding, public knowledge, publication

Serials: The Journal for the Serials Community, 2003
The argument that publicly funded research should be publicly available is a valid one, but it cannot be the most important one in the discussion as to whether research should be freely accessible. The overriding argument is that freely accessible research optimises the scientific process as well as its 'translation' into societal benefits. Free access,
openaire   +2 more sources

Effects of Thermal Discharge Upon a Subarctic Stream: Completion Report [PDF]

, 1978
The work upon which this report is based was supported in part by funds provided by the United States Department of Interior, Office of Water Research and Technology (Project B-020-ALAS), as authorized by the Water Resources Research Act of 1964 ...
Carlson, Robert F., Hok, Charlotte, Tilsworth, Timothy   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source