Results 71 to 80 of about 314,799 (305)
Public funding, public knowledge, publication
The argument that publicly funded research should be publicly available is a valid one, but it cannot be the most important one in the discussion as to whether research should be freely accessible. The overriding argument is that freely accessible research optimises the scientific process as well as its 'translation' into societal benefits. Free access,
openaire +2 more sources
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Additionality and regional development: are EU Structural Funds complements or substitutes of national Public Finance? [PDF]
This paper deals with the effects of the transfer of additional funds on the real economy of recipient countries, in particular the European Member States.
Silvia Vignetti +3 more
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Public funding of uterine transplantation [PDF]
The recent success of uterine transplantation (UTx) leading to a viable birth has provided the first evidence for the treatment and cure of absolute uterine factor infertility.1 Indeed, while its clinical and scientific merits have been recently established,1 a number of social, economic and ethical concerns remain.2–4 In particular, the question ...
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
“On the Marginal Cost of Public Funds for Argentina: CGE Evaluation and Sensitivity to Regulatory Regimes” [PDF]
We estimate the Marginal Cost of Public Funds for Argentina using a computable general equilibrium (CGE) model, assessing the sensitivity of the results to the existence of alternative regulatory regimes (Price-Cap and Cost-Plus) for public utilities ...
Cicowiez, Martín, Chisari, Omar O.
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Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Marginal Cost of Public Funds is One [PDF]
This paper develops a Mirrlees (1971) framework with heterogeneous agents to analyze optimal redistributive taxes, optimal provision of public goods and the marginal cost of public funds (MCF). Standard MCF measures are shown to suffer from three defects:
Jacobs, Bas
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Structural and cohesion funds, a financing alternative for romanian public administration [PDF]
In conditions of economic stability and, even more so, in conditions of crisis, when the budgetary resources are subjected to additional stress, public administration has an alternative financing source, by means of accessing the structural and cohesion ...
DANA MIHAELA MURGESCU
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