Results 81 to 90 of about 2,026,549 (304)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Enjeux présents et futurs du financement de l’enseignement supérieur
Revue Internationale d’Éducation de Sèvres, 2014 This article presents the theoretical bases of the human capital theory, in which education is a productive investment in the economic development of the country. Globalisation increases this pressure on education systems. The author outlines the reasons
Maria Luisa Machado Cerdeira
doaj +1 more source
Public funding of uterine transplantation [PDF]
Journal of Medical Ethics, 2016 The recent success of uterine transplantation (UTx) leading to a viable birth has provided the first evidence for the treatment and cure of absolute uterine factor infertility.1 Indeed, while its clinical and scientific merits have been recently established,1 a number of social, economic and ethical concerns remain.2–4 In particular, the question ...
openaire +2 more sources
The Erie Canal Harbor Development: Building on Community Assets for a Sustainable Future [PDF]
, 2009 This policy brief frames the redevelopment of the Erie Canal Harbor as a tool for building on our existing assets and addressing our chronic challenges.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Basic Public Finance of Public-Private Partnerships [PDF]
Public-private partnerships (PPPs) cannot be justified because they free public funds. When PPPs are desirable because the private sector is more efficient, the contract that optimally trades demand risk, user-fee distortions and the opportunity cost of ...
Alexander Galetovic +2 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
State and Service Estimates of Substance Use Treatment Facilities That Receive Public Funds in the United States. [PDF]
Subst Abuse Rehabil, 2023 Ware OD.
europepmc +1 more source
Explaining Leakage of Public Funds [PDF]
Public services, Education, Private gain ...
Reinikka, Ritva, Svensson, Jakob
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source