Results 71 to 80 of about 2,013,932 (304)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Comparative research on the correlation of the quantum to public funding for the public institutions of higher education and the institution’s performance within the European Union member states [PDF]

open access: yes
In the comparative study the authors analyze the relationship between the amount of public funds used for financing higher education, the financing mechanisms and the performance obtained by these, within the European Union member states. The performance
Florina NICOLAE   +2 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Product Market Integration and Income Taxation: Distortions and Gains from Trade [PDF]

open access: yes
It is widely perceived that globalization is a threat to tax financed public sector activities. The argument is that public activities (public consumption and transfers) financed by income taxes may distort labour markets and cause higher wages and thus ...
Allan Sörensen, Torben Andersen
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The communication of public aid in the European Union: the case of Next Generation European funds

open access: yesCommunication & Society (Formerly Comunicación y Sociedad)
In order to publicize the Next Generation funds (which will provide €806.9 billion in 2020 prices), each EU member state has had to create a portal that brings together all the information related to this instrument in accordance with the reference ...
Maria-J. Vilaplana-Aparicio   +2 more
doaj   +1 more source

Additionality and regional development: are EU Structural Funds complements or substitutes of national Public Finance? [PDF]

open access: yes
This paper deals with the effects of the transfer of additional funds on the real economy of recipient countries, in particular the European Member States.
Chiara Del Bo   +3 more
core  

Increasing Safety in America's Public Schools [PDF]

open access: yes, 2001
As the Public Education Network (PEN) and its member local education funds (LEFs) are committed to creating systems of public education that result in high achievement for every child, we believe that equal opportunity, access to quality public schools ...
Beth Bacon
core  

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