Results 91 to 100 of about 3,015,723 (281)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Factors related to the resignation and migration of physicians in public health administration agencies using nationwide survey data in Japan. [PDF]

BMC Health Serv Res, 2023
Saijo Y, Yoshioka E, Sato Y, Kunori Y.
europepmc   +1 more source

Struggling to a monumental triumph : Re-assessing the final stages of the smallpox eradication program in India, 1960-1980 [PDF]

, 2007
The global smallpox program is generally presented as the brainchild of a handful of actors from the WHO headquarters in Geneva and at the agency's regional offices.
Basu, R. N, Bonne W, Bonne W, Brilliant L. B, Brilliant L. B, Dutta Mahendra, Dutta Mahendra, Grasset N, Grasset N, Grasset N, Grasset N, Grasset N, Grasset N. c, Greenough P, Gunaratne V.T.H, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Jungalwalla N.K, Mahler H, Maltseva N, Mani C, Naraindas Harish, Payne A.M.H, Pifer John M, Sanjoy Bhattacharya, Singh Mahendra   +33 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Corruption in the public organizations. Towards a model of cost-benefit analysis for the anticorruption strategies [PDF]

The paper aims to evaluate how the anticorruption strategies lead to minimizing the corruption phenomenon in the public organizations, with special reference to those from public administration and health system in Romania.
Matei, Ani, Matei, Lucica
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Arterial hypertension registry in Vologda Region

Кардиоваскулярная терапия и профилактика, 2007
Aim. To study implementation experience of arterial hypertension (AH) diagnostics, monitoring, and control technology in Vologda Region primary healthcare system. Material and methods.
A. I. Popugaev, D. A. Rybakov, G. T. Banshchikov, A. A. Kolin'ko, R. A. Kasimov, A. M. Kalinina   +5 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The relationship between budgetary expenditure and economic growth in Poland [PDF]

This paper investigates the association between different kinds of budgetary expenditure and economic growth of Poland. The empirical analysis makes use of linear and nonlinear Granger causality tests to evaluate the applicability of Wagner’s Law and ...
Gurgul, Henryk, Lach, Lukasz, Mestel, Roland   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source