Results 71 to 80 of about 3,031,289 (335)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Strategic planning and organizational performance in public health sector: a scoping review

BMC Health Services Research
Background Strategic planning is a methodical approach to generate fundamental decisions and actions that influence and direct the nature, function, and rationale of the public health sector. However, the existing literature presents mixed findings. This
Utoomporn Wongsin, Tanavij Pannoi, Chardsumon Prutipinyo, Mohammad Ainul Maruf, Dichapong Pongpattrachai, Orawan Quansri, Youwanuch Sattayasomboon   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Willingness to pay for social health insurance among public civil servants: A cross-sectional study in Dessie City Administration, North-East Ethiopia [PDF]

, 2022
Eshetie Meseret Amilaku, Fasil Walelign Fentaye, Asnakew Molla Mekonen, Ewunetie Mekashaw Bayked   +3 more
openalex   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Study on patient perception on digital health platforms in Delhi National Capital Region

Discover Public Health
The increasing integration of digital health technologies within healthcare systems necessitates a comprehensive understanding of patient perceptions. A quantitative, cross-sectional survey approach is employed, using inferential statistical analysis to ...
Bhawna Sharma, A. Bhoomadevi, Amrish Chandra   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Social capital, health status, and sociodemographic factors associated with subjective well-being among older adults: a comparative study of community dwellings and nursing homes

BMC Public Health
Background This study aimed to examine the differences in relationships among social capital components, health status, sociodemographic characteristics, and subjective well-being (SWB) among older adults in institutionalized versus non-institutionalized
Yan Chen, Dahui Wang, Wenhao Chen, Enxi Zhao, Wanjing Li, Shanshan Zhu, Xianlan Wu   +6 more
doaj   +1 more source

What Can Public Health Administration Learn from the Decision-Making Processes during COVID-19? [PDF]

Int J Environ Res Public Health, 2023
Joyce A, Risely E, Green C, Carey G, Buick F.   +4 more
europepmc   +1 more source