Results 91 to 100 of about 2,676,824 (308)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Television News Coverage of Public Health Issues and Implications for Public Health Policy and Practice.

Annual Review of Public Health, 2019
Television (TV) news, and especially local TV news, remains an important vehicle through which Americans obtain information about health-related topics. In this review, we synthesize theory and evidence on four main functions of TV news in shaping public
Sarah E. Gollust, E. Fowler, Jeff Niederdeppe   +2 more
semanticscholar   +1 more source

Public Health Workforce Self-Identified Training Needs by Jurisdiction and Job Type

, 2018
Context: Ensuring adequate and appropriate training of the workforce is a crucial priority for governmental public health. This is particularly important, given the diverse backgrounds of the public health workforce; the vast majority (approximately 83%)
Wisniewski, Janna M., Castrucci, Brian, Gould, Elizabeth, Yeager, Valerie A., Chapple-McGruder, Theresa   +4 more
core   +1 more source

A cluster-randomized trial of a complex intervention to encourage deprescribing antidepressants in nursing home residents with dementia: a study protocol

Trials, 2022
Background The effectiveness of psychotropic medication on behavioral and psychological symptoms of dementia (BPSD) is limited, while associated with a higher risk of adverse events.
Pernille Hølmkjær, Anne Holm, Gritt Overbeck, Maarten Pieter Rozing   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Health Equity and Ethical Considerations in Using Artificial Intelligence in Public Health and Medicine

Preventing Chronic Disease
This commentary explores the critical roles of health equity and ethical considerations in the deployment of artificial intelligence (AI) in public health and medicine.
Irene Dankwa-Mullan
semanticscholar   +1 more source

Building capacity for evidence-based public health: Reconciling the pulls of practice and the push of research

Annual Review of Public Health, 2017
Timely implementation of principles of evidence-based public health (EBPH) is critical for bridging the gap between discovery of new knowledge and application.
R. Brownson, J. Fielding, L. Green
semanticscholar   +1 more source

Traveller Focus Week - improving health and wellbeing

, 2011
Members of the Traveller community and their support organisations joined the Public Health Agency and the Health and Social Care Board at an event in Dungannon to mark Traveller Focus Week (5 - 11 December) by sharing the progress made, and celebrating ...
Public Health Agency
core   +1 more source

Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study

BMC Medicine
Background The prevalence of multimorbidity is increasing and is associated with polypharmacy (PP) and a reduced quality of life (QoL). Polypharmacy consistently correlates with poorer outcomes; however, its relationship with QoL in a broad general ...
Henrik Hedegaard Pliess Larsen, Volkert Siersma, Tora Grauers Willadsen, Anna Bernhardt Lyhnebeck, Anders Prior, Frans Boch Waldorff, Anne Holm   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source