Results 81 to 90 of about 2,676,824 (308)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Obesity - an acknowledged public health challenge

, 2011
As we face a difficult economic climate, in which inequalities may worsen, the PHA faces many challenges in its efforts to improve the health of the population. One such challenge is the issue of obesity.
Public Health Agency
core   +1 more source

Master of Public Health Concentrations in Global Health in 2020: Preparing Culturally Competent Professionals to Address Health Disparities in the Context of Globalization

, 2021
During the 2019-2020 academic year, 37 (17%) of 223 Council on Education for Public Health (CEPH) accredited or applicant schools and programs of public health offered Master of Public Health (MPH) degrees with concentrations in general global health ...
Malouin, Rebecca, Waggett, Caryl E., Zeraye, Helen A., Jacobsen, Kathryn H., Gartin, Meredith, Bisesi, Michael S.   +5 more
core   +1 more source

A cluster-randomized study to evaluate the effectiveness and cost-effectiveness of the Assessment of Burden of Chronic Conditions (ABCC) tool in South Tyrolean primary care for patients with COPD, asthma, type 2 diabetes, and heart failure: the ABCC South Tyrol study

Trials
Background Chronic diseases, such as chronic obstructive pulmonary disease (COPD), asthma, type 2 diabetes, and heart failure, often coexist and contribute to a significant burden on individuals and health systems.
Christian J. Wiedermann, Pasqualina Marino, Angelika Mahlknecht, Verena Barbieri, Giuliano Piccoliori, Adolf Engl, Annerika H. M. Gidding-Slok   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Integrating Public Health into Climate Change Policy and Planning: State of Practice Update

International Journal of Environmental Research and Public Health, 2019
Policy action in the coming decade will be crucial to achieving globally agreed upon goals to decarbonize the economy and build resilience to a warmer, more extreme climate. Public health has an essential role in climate planning and action: “Co-benefits”
M. Fox, Christopher Zuidema, Bridget Bauman, T. Burke, M. Sheehan   +4 more
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Family-Focused Public Health: Supporting Homes and Families in Policy and Practice

Frontiers in Public Health, 2019
Life expectancy in the US is on the decline. Mental health issues associated with opioid abuse and suicide have been implicated for this decline necessitating new approaches and procedures.
C. Hanson, A. Crandall, Michael D Barnes, Brianna M. Magnusson, M. L. Novilla, J. King   +5 more
semanticscholar   +1 more source

Preventing Leader Derailment—A Strategic Imperative for Public Health Agencies

, 2018
Public health leaders, such as those who serve as state health officials (SHOs), routinely face challenges that are uncertain and complex. Those who reflect on the challenges they face and use those reflections to improve themselves and their teams ...
Sharon Moffatt, Moffatt, Sharon, Steven F. Boedigheimer, Paul K. Halverson, Edward L. Baker, Halverson, Paul K., Baker, Edward L., Boedigheimer, Steven F., Altman, David, Castrucci, Brian C., Brian C. Castrucci, David Altman   +11 more
core   +1 more source

Evidence-based public health practice [PDF]

Australian and New Zealand Journal of Public Health, 1999
Public health decisions that are based on critical appraisal of the best available evidence will lead to the development of interventions that have the maximum potential to impact on the health and well-being of the community. The principles of evidence-based practice are now well established for clinical medicine.
Glasziou, P., Longbottom, H.
openaire   +5 more sources