Results 61 to 70 of about 5,645,039 (315)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Impact of travel ban implementation on COVID-19 spread in Singapore, Taiwan, Hong Kong and South Korea during the early phase of the pandemic: a comparative study

BMC Infectious Diseases, 2021
Background The COVID-19 pandemic has elicited imposition of some form of travel restrictions by almost all countries in the world. Most restrictions currently persist, although some have been gradually eased.
Sylvia Xiao Wei Gwee, Pearleen Ee Yong Chua, Min Xian Wang, Junxiong Pang   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

PHOENIX: Public Health and Obesity in England – the New Infrastructure eXamined First interim report: the scoping review [PDF]

, 2015
The PHOENIX project aims to examine the impact of structural changes to the health and care system in England on the functioning of the public health system, and on the approaches taken to improving the public’s health. The scoping review has now been
Bramwell, Donna, Coleman, Anna, Gadsby, Erica W., Jenkins, Linda M., Peckham, Stephen, Perkins, Neil, Segar, Julia   +6 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Impact of mHealth interventions on maternal, newborn, and child health from conception to 24 months postpartum in low- and middle-income countries: a systematic review

BMC Medicine
Background Mobile health (mHealth) technologies have been harnessed in low- and middle-income countries (LMICs) to address the intricate challenges confronting maternal, newborn, and child health (MNCH).
Marianne Ravn Knop, Michiko Nagashima-Hayashi, Ruixi Lin, Chan Hang Saing, Mengieng Ung, Sreymom Oy, Esabelle Lo Yan Yam, Marina Zahari, Siyan Yi   +8 more
doaj   +1 more source

The Effect of Unintended Pregnancy Among Married Women on the Length of Breastfeeding in Indonesia

Jurnal Ilmu Kesehatan Masyarakat, 2020
The coverage of exclusive breastfeeding in Indonesia in 2017 is 35%, far below the recommendations of WHO (World Health Organization) of 50%. This rate is getting lower in unwanted pregnancies.
Lia suryani, Amrina Rosyada
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

New Public Health and National Public Health System

Journal of agricultural medicine and community health, 2012
The New Public Health(NPH) is a comprehensive approach to protecting and promoting the health status of each individual member and society as a whole. NHP is not so much a philosophy to broaden the understanding of public health as it is an action plan to address current public health system.
openaire   +2 more sources

Development and preliminary testing of a patient reported experience measure for chronic disease patients in Singapore

BMC Health Services Research
Background Patient experience is invaluable for identifying gaps in the provision of healthcare. Patient-Reported Experience Measures (PREMs) are essential tools for evaluating the quality of care from the patient’s viewpoint.
Yiyun Shou, Jia Jia Lee, Lay Hoon Goh, Cynthia Chen, Ngan Phoon Fong, Le Ann Chen, Oyvind Bjertnaes, Jose M. Valderas, Nan Luo   +8 more
doaj   +1 more source