Results 131 to 140 of about 5,437,298 (346)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

The Intersection of Art and Public History: Schmucker Art Gallery’s Newest Exhibit

open access: yes, 2015
“‘Pray For the People Who Feed You’: Voices of Pauper Children in the Industrial Age” is the newest exhibit to be featured in the Schmucker Art Gallery at Gettysburg College.
Lauck, Jeffrey L.
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Royal Biography Between the Lines: Georgette Heyer’s Regency Romances and the Life of Princess Charlotte of Wales (1796-1817).

open access: yesRoyal Studies Journal
This article considers the topic of writing royal lives from an interdisciplinary perspective which embraces questions of popular history and particularly historical fiction.
Sarah Betts
doaj  

I campi di concentramento fascisti. La memoria italiana tra miti, silenzi e public history

open access: yesDiacronie. Studi di Storia Contemporanea, 2018
In the first part, the article presents a brief review of the steps that have marked the progressive rediscovery of the fascist concentration camps by Italian historiography.
Irene Bolzon, ha conseguito il dottorato di ricerca presso l’Università degli Studi di Udine in Storia, culture e strutture della aree di frontiera. È direttrice dell’Istresco, membro del comitato scientifico dell’Istituto nazionale “Ferruccio Parri” e del direttivo dell’Irsrec-Fvg. Tra i suoi temi di ricerca la questione del confine orientale, la violenza del fascismo repubblicano e la giustizia politica in Italia nel secondo dopoguerra.
doaj  

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