Results 71 to 80 of about 3,681,565 (356)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Interventional radiology practice in a tertiary hospital in South Africa: A 5-year record review

South African Journal of Radiology
Background: Interventional radiology (IR) is a rapidly advancing speciality which uses various imaging modalities to guide diagnostic and therapeutic procedures.
Gaone Madingwane, Dale K. Creamer
doaj   +1 more source

Public Employment and Political Pressure: The Case of French Hospitals [PDF]

This paper uses an unusual administrative dataset covering the universe of French hospitals to consider hospital employment: this is consistently higher in public hospitals than in Not-For-Profit (NFP) or private hospitals, even controlling for a number ...
Clark, Andrew E., Milcent, Carine
core  

Evaluation of Lactation Promotion as Part of Baby Friendly Hospital [PDF]

, 2017
Decrease of maternal and infant mortality as well as increasing of the exclusive breastfeeding are major public health priorities in Indonesia. In decreasing the maternal and infant mortality, the government developed a program for the community as Baby ...
Handayani, L. (Lina), Inayah, A. L. (Arsani), Saufi, A. (Azidanti)   +2 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

How is the Cost Structure of Hospital in Developing Countries? A Case of Public University Hospitals in Iran [PDF]

Journal of Health Management & Informatics, 2020
Background: The health systems around the world are facing significant pressure to control the costs and improve the health services delivered. A method to address this challenge is to express the potential savings and inefficiencies of hospitals.
mohammad saleh koushki, Mahmoud Nekooei Moghaddam, Mohammadreza Amiresmaili, Reza Goudarzi, Vahid Yazdi-Feyzabadi   +4 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Centralisation of financial decision-making on public hospitals in the Eastern Cape province

Africa’s Public Service Delivery & Performance Review
Background: The formal introduction of national health insurance in 2011 is making significant progress in South Africa. However, coronavirus disease 2019 (COVID-19) and the current financial situation pose a new challenge to South Africa’s ailing public
Thanduxolo Fana, Mosekama O. Mokhele
doaj   +1 more source

International Profiles of Health Care Systems, 2012 [PDF]

, 2012
This publication presents overviews of the health care systems of Australia, Canada, Denmark, England, France, Germany, Japan, Iceland, Italy, the Netherlands, New Zealand, Norway, Sweden, Switzerland, and the United States.

core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source