Results 141 to 150 of about 1,532,901 (351)

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

open access: yesAdvanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li   +13 more
wiley   +1 more source

Addressing urban social and spatial stratification: testing the potential for integration of public housing

open access: yesArchitecture_MPS
The legacy of public housing in the American city is dominated by a condition of social and spatial stratification. In New York City, inadequate funding exacerbates the conditions of isolated public housing residents, raising questions about the ...
doaj   +2 more sources

School Quality and Housing Prices: Empirical Evidence Based on a Natural Experiment in Shanghai, China [PDF]

open access: yes
The extent to which the quantity and quality of education is capitalized into housing prices is a key issue in understanding the relationship between allocation of educational resources and the housing market.
Hao Feng, Ming Lu
core  

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

open access: yesAdvanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv   +8 more
wiley   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

open access: yesAdvanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li   +12 more
wiley   +1 more source

Helping Public Housing Residents Find and Keep Jobs: A Guide for Practitioners Based on the Jobs-Plus Demonstration [PDF]

open access: yes, 2008
This guide contains practical advice on implementing a program model -- known as the Jobs-Plus Community Initiative for Public Housing Families (Jobs-Plus) -- aimed at helping public housing residents find and keep jobs.
Donna Wharton-Fields, Susan Blank
core  

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

open access: yesAdvanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang   +9 more
wiley   +1 more source

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