Results 71 to 80 of about 29,817,608 (260)

Information systems evaluation in the public sector [PDF]

, 2002
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Investment appraisal techniques (TAT) range from quantitative (financially based) techniques to qualitative (non-financially based) techniques, and ...
Khalifa, Ghassan R
core   +5 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Student studying in dorm room

, 1960
Student studying in a dorm room at Pacific University in the 1960s.[back] Office of Public Information, Pacific University, Forest Grove, Oregon, 97116; student life pre ...
Office of Public Information, Pacific University, Forest Grove, Oregon, publisher
core   +1 more source

THE IMPORTANCE OF COMMUNICATION IN THE PROCESS OF INTEGRATION IN THE EUROPEAN UNION: CASE STUDY OF THE REPUBLIC OF MACEDONIA [PDF]

Journal of Process Management and New Technologies, 2013
Facing the challenges of the new changes and reforms on the way towards accessing the European Union, the Republic of Macedonia is also facing the challenge to strengthen the capacities of the administration, which inevitably means informing it ...
Suzana Dzamtovska - Zdravkovska, Jadranka Denkova, Andon Majhosev   +2 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Student studying at Pacific University

, 1960
Unidentified student studying at Pacific University in the 1960s.[back] Office of Public Information, Pacific University, Forest Grove, Oregon, 97116; student life pre 1970 ...
Office of Public Information, Pacific University, Forest Grove, Oregon, publisher
core   +1 more source

Pengecualian Keterbukaan Informasi Publik atas Dasar Rahasia Intelijen dalam Undang-Undang Nomor 14 Tahun 2008

Jurnal Nuansa Akademik
Public information disclosure is a constitutional right guaranteed in a democratic state. This normative legal research aims to identify clear rules regarding the limits of intelligence secrecy in Law Number 14 of 2008 concerning Public Information ...
Alfin Yuza Pratama, Hartati Hartati, Arfai Arfai   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Gloss on the judgement of the Supreme Administrative Court of 21 October 2022, III OSK 4468/21 (concerning the provision of public information by a foundation)

Ius Novum
In its judgment of 21 October 2022, III OSK 4468/21, the Supreme Administrative Court considered that a foundation is obliged to provide public information because, in accordance with Article 1 of the Act on Foundations, it should accomplish socially and
Przemysław Szustakiewicz
doaj   +1 more source