Results 141 to 150 of about 3,624,559 (303)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Institutional Theories and Public Institutions. [PDF]
This chapter covers the evolution of institutional theory and its application to public adminsitrations in the last 20 years. It discusses the various streams, their reseach agendas and their contributions, but also their limits to add value to knowledge.
Jean-Claude Thoenig
core
Citizen Mobilization and Community Institutions: the Public Education Network's Policy Initiatives - Executive Summary [PDF]
, 2006 The executive summary for a report that analyzes the results of a bold set of initiatives designed to stimulate and support public responsibility for public education in 14 locales around the country.
Brenda J. Turnbull
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Predicting strategic change of public research institutions under unstable negative growth [PDF]
The purpose of this paper is to forecast and analyse, by a demographic perspective, the organizational behaviour of public research labs. The research focuses on the biggest Italian public research body.
Mario Coccia
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Communication strategy of the National Museum of Natural History ”Grigore Antipa”
Transylvanian Review of Administrative Sciences, 2007 Due to the amplitude of the communication techniques in the public area in Western Countries and the spectacular development of publicity and public relations in this field, we find it interesting to analyze how and if this measure can be applied by ...
Ruxandra Irina POPESCU
doaj
Strategies Implemented by Public Institutions to Approach the Judicialization of Health Care in Brazil: A Systematic Scoping Review. [PDF]
Front Pharmacol, 2020 Yamauti SM +3 more
europepmc +1 more source