Results 81 to 90 of about 3,671,729 (308)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Growth, Public Investment and Corruption with Failing Institutions [PDF]

open access: yes
Corruption is thought to prevent poor countries from catching-up. We analyze one channel through which corruption hampers growth: public investment can be distorted in favor of specific types of spending for which rent-seeking is easier and better ...
Clara Delavallade, David de la Croix
core   +3 more sources

Public institutions of “high” culture [PDF]

open access: yes, 2015
This chapter focuses on institutions that distribute “high” culture via public or quasi-public mechanisms. High culture includes (Western) fine arts, such as classical and contemporary visual arts, opera, classical music, and ballet. The chapter covers art museums, symphony orchestras, and opera, drama, and dance companies, organizations comprising ...
openaire   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Global, Regional, and National Burden and Quality of Care Index (QCI) of Motor Neuron Disease: A Systematic Analysis of the Global Burden of Disease Study 1990 to 2021

open access: yesMed Research
In 2021, there were 64,178 new cases of motor neuron disease (MND) worldwide, resulting in 39,082 deaths. However, from 1990 to 2021, the global care quality for MND did not show significant improvement, with disparities observed across ages, genders ...
Huilin Xia   +7 more
doaj   +1 more source

Higher Education Collaboratives for Community Engagement and Improvement [PDF]

open access: yes, 2005
Our society is in a period of dramatic change with the transition from an industrial-based to a knowledge-based economy, as well as technological advances, fiscal challenges of higher education, and cultural shifts in society as a whole.
Bowman, Nick   +4 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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