Results 41 to 50 of about 2,228,945 (247)
Tools shape practice shapes tools...
Revista TeknokulturaThis article narrates a partial history of two decades of doing graphic design with free, libre and open-source tools. We follow the development of tools and practices that allowed graphic design practice to shift, such as layouts being generated by ...
Manetta Berends, Femke Snelting
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Public Diplomacy in the Public Interest
Journal of Public Interest Communications, 2017 As public diplomacy becomes a more collaborative, socially conscious enterprise with increased focus on global issues, problem-solving and shared goals, public interest communications--or strategic communication efforts to influence outcomes on issues ...
Kathy Fitzpatrick
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
European Journal of General PracticeBackground Social prescribing (SP) is a patient pathway by which healthcare professionals connect patients with other sources of support, groups, or activities within their community.
Sinah Evers +6 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Economic Politics, between Individual Interest and Public Interest [PDF]
Theoretical and Applied Economics, 2006 According with A. Smith “by pursuing his own interest individual frequently promotes that of society more effectually than when he really intends to promote it.” But what is the passing way from individual interest to public interest?
Dorel Ailenei
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BMJ OpenObjective To develop expert consensus on best practice approaches to social prescribing (SP) in European primary care, with a focus on the roles, competencies and implementation conditions for social prescribing link workers (SPLWs).Design A three-round ...
Kerryn Husk +53 more
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