Results 111 to 120 of about 2,639,699 (314)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Health ExpectationsIntroduction Health inequities disproportionately affect people from ethnic minority communities and require a comprehensive effort across healthcare disciplines to tackle them.
Caitlin Shaw +3 more
doaj +1 more source
Schools Respond to Risk Management Programs for Asbestos, Lead in Drinking Water and Radon [PDF]
, 1993 Based on a study of the three EPA-initiated, public school risk management programs noted in the title, the authors find that state agency involvement is an important factor in the success of such programs. They also find, e.g., that school districts are
Chapman, Ruth H. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The rise and fall of the patient forum [PDF]
The circular, ‘A Stronger Local Voice’ (Department of Health 2006) published in July announced that Patient Forums in England will be abolished to be replaced by local authority run Local Involvement Networks (LINks). What went wrong with Forums?
Warwick, Philip
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Co-production as the ultimate goal; an incentive or discouragement?
Research Involvement and EngagementPatient and public involvement (PPI) in research is a requirement in most of the western world. Funders routinely require extensive PPI plans from applicants and co-production is seen as the ultimate goal.
A. Bangiri +5 more
doaj +1 more source
The Benefits of Campaign Spending [PDF]
, 2003 Critics of American politics often say that spending on electoral campaigns harms our democracy. They charge that the money goes for cynical, negative, and misleading advertisements that alienate the public from politics and elections.
John J. Coleman
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