Results 141 to 150 of about 18,200,324 (304)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Public Health Agency Business plan 2012-2013
, 2012 This Business Plan sets out the key priorities and actions that will be progressed by the Public Health Agency (PHA) in 2012/13. The PHA believes that these actions will have the biggest impact on improving levels of health and social wellbeing ...
Public Health Agency
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
National Library Week at the Oskaloosa Public Library Key, 1962; Mahaska County; Iowa
, 1962 This is a key that goes with the photograph taken at the Oskaloosa Public Library during National Library Week ...
Oskaloosa Public Library
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, 1969 A reproduction of a map of Siesta Key by Siesta Key Palmer Bank. The map was originally made based on surveys by J.P. Apthorp in 1876 and 1895. Additions were added from a map of territory tributary to Sarasota in 1916 and information from the Sarasota
Siesta Key Palmer Bank
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
NTRU-Like Random Congruential Public-Key Cryptosystem for Wireless Sensor Networks. [PDF]
Sensors (Basel), 2020 Ibrahim A +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Public Key Encryption with Keyword Search in Cloud: A Survey. [PDF]
Entropy (Basel), 2020 Zhou Y, Li N, Tian Y, An D, Wang L.
europepmc +1 more source