Results 41 to 50 of about 18,074,471 (294)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Cryptography. key exchange, public key
CoRR, 2013 General cryptographic schemes are presented where keys can be one-time or ephemeral. Processes for key exchange are derived. Public key cryptographic schemes based on the new systems are easily established. Authentication and signature schemes are implemented.
openaire +3 more sources
Attacking Tropical Stickel Protocol by MILP and Heuristic Optimization Techniques
Journal of Cybersecurity and PrivacyKnown attacks on the tropical implementation of Stickel protocol involve finding minimal covers for a certain covering problem, and this leads to an exponential growth in the worst case time required to recover the secret key as the used polynomial ...
Sulaiman Alhussaini, Sergeĭ Sergeev
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MUTUAL LEARNING IN TREE PARITY MACHINES USING CUCKOO SEARCH ALGORITHM FOR SECURE PUBLIC KEY EXCHANGE
ICTACT Journal on Soft Computing, 2018 In Neural Cryptography, Artificial Neural Networks are used for the process of key generation and encryption. Tree Parity Machine (TPM) is a single layer neural network that approaches symmetric key exchange using the process of mutual learning.
Shikha Gupta +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Improved cryptanalysis of a ElGamal Cryptosystem Based on Matrices Over Group Rings
Journal of Mathematical Cryptology, 2020 ElGamal cryptosystem has emerged as one of the most important construction in Public Key Cryptography (PKC) since Diffie-Hellman key exchange protocol was proposed. However, public key schemes which are based on number theoretic problems such as discrete
Pandey Atul +2 more
doaj +1 more source
The Digital Signature of Blum-Goldwasser Probobilistic Public Key Cryptosystem [PDF]
, 1999 The digital signature algorithm for Blum-Goldwasser probabilistic public key cryptosystem is proposed. In the proposed cryptosystem both encryption and digita1 signature can be done at the same time. The security of the proposed cryptosystem is not lower
ODAKA, Tomohiro +7 more
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