Results 141 to 150 of about 14,773,662 (288)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

open access: yesAdvanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin   +20 more
wiley   +1 more source

Efficiency Evaluation and Influencing Factors of Chinese Public Libraries: On the Information Construction and Four-Stage Super-SBM DEA Model

open access: yesSAGE Open
Analyzing the efficiency of public libraries is an important prerequisite for realizing the rational allocation of public library resources and balanced regional development.
Hui Li, Ning Liu, Yong Tan
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Public Libraries & Knowledge Centers newsletter

open access: yes, 2008
This publication contains may contain links to external sites. These external sites may no longer be active.Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).This publication contains many links to ...
Public Libraries and Knowledge Centres
core  

Zero Censorship! Who Are We Kidding?An exploratory analysis of the opinions and experiences of Queensland-based public librarians with regard to the censorship of materials in public library collections [PDF]

open access: yes, 2004
Public librarians have long upheld the social justice philosophy of free access to information for all people. The issue of censorship is related to both the professional principles of the Australian Library and Information Association and to the role ...
Moody, Kim E., Moody, Kim
core   +1 more source

High Citation of Iranian Coauthored articles in comparison with single authored ones: does it link with self-citation

open access: yesIranian Journal of Information Processing & Management, 2012
The aim of this research was to investigate the effect of co-authorship and self-citation on the citation rates of Iranian indexed articles in Web of Science (WoS).
Seaid Nazarian   +2 more
doaj  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen   +20 more
wiley   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

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