Results 141 to 150 of about 332,105 (306)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang   +12 more
wiley   +1 more source

Youth services and public libraries /

open access: yes, 2007
Youth Services and Public Libraries offers strategies to match the information needs and wants of children and young adults in public libraries and translates these into knowledge for providing relevant services.
Higgins, Susan E.(Assistant professor)
core  

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang   +19 more
wiley   +1 more source

The Next Generation Online Public Access Catalog in Academic Libraries [PDF]

open access: yes, 2009
"Make it more like Google" is a refrain that is often heard by students at academic libraries when asked how library catalogs can be improved. According to the annual Beloit College Mindset list for the class of 2010, the word Google has always been a ...
Wallis, Kim
core  

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

open access: yesAdvanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu   +17 more
wiley   +1 more source

Funding Dilemma in Pakistani Libraries: Causes, Effects, Responses

open access: yes, 2006
Literature on funding problems of Pakistani libraries reveals that poor economy of the country, inflation, low priority to education and price increase of library material are the main causes of this dilemma.
Hameed, Abdul   +2 more
core  

Efficiency Evaluation and Influencing Factors of Chinese Public Libraries: On the Information Construction and Four-Stage Super-SBM DEA Model

open access: yesSAGE Open
Analyzing the efficiency of public libraries is an important prerequisite for realizing the rational allocation of public library resources and balanced regional development.
Hui Li, Ning Liu, Yong Tan
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

High Citation of Iranian Coauthored articles in comparison with single authored ones: does it link with self-citation

open access: yesIranian Journal of Information Processing & Management, 2012
The aim of this research was to investigate the effect of co-authorship and self-citation on the citation rates of Iranian indexed articles in Web of Science (WoS).
Seaid Nazarian   +2 more
doaj  

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