Results 281 to 290 of about 379,591 (337)

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

The role of information science within the clinical translational science ecosystem. [PDF]

J Clin Transl Sci
Ragon B, Seymour A, Whipple EC, Surkis A, Haberstroh A, Muilenburg J, Rethlefsen ML, Aspinall EE, Deaver J, Dexter N, Barger R, Contaxis N, Glenn EJ, Hinton E, Kern B, Little M, Pickett K, Sevetson E, Tao D, von Isenburg M, Werner DA, Wheeler TR, Holmes K.   +22 more
europepmc   +1 more source

Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague

Advanced Science, EarlyView.
The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Uri Elia, Yinon Levy, Hila Cohen, Ayelet Zauberman, David Gur, Inbal Hazan‐Halevy, Moshe Aftalion, Shani Benarroch, Erez Bar‐Haim, Orit Redy‐Keisar, Ofer Cohen, Dan Peer, Emanuelle Mamroud   +12 more
wiley   +1 more source

Correction: Is functional training functional? a systematic review of its effects in community-dwelling older adults. [PDF]

Eur Rev Aging Phys Act
Liu CJ, Chang WP, Shin YC, Hu YL, Morgan-Daniel J.   +4 more
europepmc   +1 more source

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

FIORA: Local neighborhood-based prediction of compound mass spectra from single fragmentation events. [PDF]

Nat Commun
Nowatzky Y, Russo FF, Lisec J, Kister A, Reinert K, Muth T, Benner P.   +6 more
europepmc   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Retrospective SARS-CoV-2 human antibody development trajectories are largely sparse and permissive. [PDF]

Proc Natl Acad Sci U S A
Kirby MB, Petersen BM, Faris JG, Kells SP, Sprenger KG, Whitehead TA.   +5 more
europepmc   +1 more source

Single-cell chromatin landscapes associated with the burnt skin healing process in rats. [PDF]

Sci Data
Wang T, Zhu B, Lu J, Guo X, Li R, Yuan Y, Chen J, Dai X, Liu S, Du J, Xu X, Liu H, Wei X, Huang R, Ji S.   +14 more
europepmc   +1 more source

GeneSetCart: assembling, augmenting, combining, visualizing, and analyzing gene sets. [PDF]

Gigascience
Marino GB, Olaiya S, Evangelista JE, Clarke DJB, Ma'ayan A.   +4 more
europepmc   +1 more source