Results 291 to 300 of about 9,320,919 (411)

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

open access: yesAdvanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan   +11 more
wiley   +1 more source

Leishmaniases in Kenya: a scoping review subanalysis of vectors. [PDF]

open access: yesBMJ Open
O'Brien K   +13 more
europepmc   +1 more source

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

open access: yesAdvanced Science, EarlyView.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong   +11 more
wiley   +1 more source

Echoes in the Deep: Revealing Influenza A Viruses' Persistence and Microbial Associations in Aquatic Ecosystems. [PDF]

open access: yesTransbound Emerg Dis
Chen W   +16 more
europepmc   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

open access: yesAdvanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li   +6 more
wiley   +1 more source

City-wide built environment SARS-CoV-2 detection for COVID-19 surveillance. [PDF]

open access: yesPLOS Glob Public Health
MacFadden DR   +15 more
europepmc   +1 more source

Self‐Assembled Moiré Superlattices of Ti3C2Tx MXene for Future Twistronic Applications

open access: yesAdvanced Science, EarlyView.
Scanning tunneling microscopy imaging reveals self‐assembled Moiré superlattices in MXene with distinct periodicities. The observed Moiré modulates the local density of states due to interlayer electronic coupling. This work provides an atomic‐scale understanding of MXene Moiré physics and establishes a foundation for twistronics in future quantum ...
Kuanysh Zhussupbekov   +9 more
wiley   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

open access: yesAdvanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh   +11 more
wiley   +1 more source

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