Results 71 to 80 of about 6,827,236 (342)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Personal factors influencing the information behavior of scientists and specialists
Библиосфера, 2018 The article reviews results of the surveying scientists employees of scientific centers of the Siberian Branch of the Russian Academy of Sciences - to study their information behavior. It reveals researchers’ preferences, peculiarities of their work with
O. L. Lavrik +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Partnering Public Library services with Public Schools
WOW Stories, 2013 The Washington County Public Library worked with kindergarten teachers to implement lessons that would broaden the students' understandings of global cultural through global picturebooks and crafts, food, and music. This vignette discusses the books read,
Heather Dantzler , Jessica Ross
doaj
Библиосфера, 2019 The value-semantic paradigm of the library science’ knowledge undergoes constant changes understandable only in the context of its evolution. It is due to a number of factors, namely: transformation of the scientific knowledge system as a whole; changes ...
G. M. Vikhreva, O. P. Fedotova
doaj +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Electronic union catalog of the Siberian and Far Eastern books as a historical information resource
Библиосфера, 2018 The article gives a brief overview of research on the problems of preparing union catalogs; it shows that the creation of the national union catalogs’ system is a strategic direction for the library and information science development in Russia.
O. L. Lavrik +2 more
doaj +1 more source