BackgroundSocial media platforms have emerged as prominent channels for disseminating cardiovascular health information. However, the accuracy, completeness, and clinical reliability of cardiac rehabilitation (CR)-related content vary widely.
Jie Yuan +5 more
doaj +1 more source
Current drivers and facets of the Ukraine-Slovak cross-border cooperation in line with eurointegration and sustainable development goals [PDF]
The Eurointegration and the Sustainable Development Goals mark the benefits of peaceful, human-rights oriented, balanced and participative cooperation between states, regions, communities, entities and individuals.
Alevtyna Sanchenko , Volodymyr Ustymenko
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
ČITANJE I ČITATELJSKE NAVIKE – PRIKAZ REZULTATA ISTRAŽIVANJA PROVEDENIH U SKLOPU PILOT-PROJEKTA ČITAJMO DRŽIĆA DOMA MARINA DRŽIĆA U DUBROVAČKIM OSNOVNIM ŠKOLAMA [PDF]
Čitanje je složen proces koji se odnosi na „sposobnost apstrahiranja informacija iz teksta i njihova ispravnog interpretiranja“ te je ujedno i proces u kojem se uspostavlja prisan, emocionalni odnos s tekstom u kojem sudjeluju sva osjetila.
Katja Bakija, Marija Konsuo Kuzmanić
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Public media lobbying: the case of APTS
This paper focuses on the governance structure that links US public television station’s largest federal lobbying firm (America’s Public Television Stations or APTS) with the recently approved ATSC 3.0 broadcast standard, in which APTS is a major ...
Christopher Ali, Sydney Forde
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source

