Results 41 to 50 of about 804,583 (218)

Reinterpretations of Kant’s and Hegel’s philosophy in Fukuyama’s vision of global dominance of liberal democracy [PDF]

Annales Scientia Politica, 2023
Reinterpretations of Kant’s and Hegel’s philosophy in Fukuyama’s vision of global dominance of neoliberalism comprise the leitmotif of the submission. Utilizing the method of comparing source texts, authors of the submission call attention to the fact ...
Rudolf Dupkala
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Assessing The Influence of Media Ownership on Journalism Practice: A Case Study of ZNBC TV1 and ZNBC Radio 1

Journal of Arts, Humanities and Social Science
Media play an important role of informing, entertaining and educating society. Its significance and influence whether electronic or print media plays an undeniable role in today’s world.
Natasha Mwalimu, Sycorax T. Ndhlovu
doaj   +1 more source

Czechoslovak Social Democracy in Exile and its last chairman, Karel Hrubý [PDF]

Annales Scientia Politica, 2022
The study analyzes the development of the exiled organization of the Social Democrats from Czechoslovakia in the years 1948-1995. It shows its anticommunist background, which has remained within the organization throughout its existence, which has in ...
Tomáš Zahradníček
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Media and Democracy in Crisis. A Comparative Analysis of Images of the Riots in the USA in the Public Media of Germany, Poland, and Russia

Polish Political Science Yearbook
This article presents a diverse European perspective on democracy and freedom of expression. The research was conducted on 73 public television materials after the storming of the Capitol in Germany, Poland, and Russia.
Dagmara Głuszek-Szafraniec, Patrycja Szostok-Nowacka   +1 more
doaj   +1 more source

Regional economic development of the Slovak-Ukrainian borderlands [PDF]

Annales Scientia Politica, 2022
The article provides an overview of regional economic indicators of the Slovak-Ukrainian borderlands in the period 2010 – 2020, following the Regional economic performance index ranking. It focuses on economic performance, socio-economic characteristics,
Martin Lačný, Mária Kováčová
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source