Results 51 to 60 of about 804,583 (218)

Modern philosophy: Doubt and duty as a moral principle [PDF]

Annales Scientia Politica, 2020
The paper discusses two important intentions of moral philosophizing within the modern age philosophy. We mean the concept of the morality of doubt and the morality of duty.
Peter Gustáv Hrbatý
doaj  

Emotions in the study of international relations [PDF]

Annales Scientia Politica, 2023
The article discusses the debate about emotions in the study of international relations. Traditional theories such as realism and liberalism are built upon fear or, conversely, empathy.
Michaela Zemanová
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Digital Transformation in Institutional Communication: A Systematic Review of Transparency, Trust, and Organizational Culture

Journalism and Media
This study aims to analyze digital transformation in institutions as a structural shift that reshapes the logic of communication, patterns of power, and mechanisms of trust building within organizations.
Rahima Aissani, Haneen Mohammad Shabaneh, Haneen Bahij Kanaan, Ibrahim Ibrahim Elshenawy   +3 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

What could go wrong? Reflections and roadmap for successfully engaging with public media. [PDF]

J Am Geriatr Soc, 2023
Fohner AE, Whitson HE, Aronson L.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Public Media Autonomy and Accountability: Best and Worst Policy Practices in 12 Leading Democracies

International Journal of Communication, 2017
Public media’s contributions to democracy are well established. Less widely known are the specific policies that make these contributions possible. This study finds that professional autonomy and civic accountability in public media are supported by (1)
Rodney Benson, Matthew Powers, Timothy Neff   +2 more
doaj  

180 years of marine animal diversity as perceived by public media in southern Brazil. [PDF]

PLoS One, 2023
Herbst DF, Rampon J, Baleeiro B, Silva LG, Fossile T, Colonese AC.   +5 more
europepmc   +1 more source