Results 31 to 40 of about 29,315,787 (303)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

OPEN PUBLIC SPACE ATTRIBUTES AND CATEGORIES – COMPLEXITY AND MEASURABILITY [PDF]

AR: Arhitektura, Raziskave, 2014
Within the field of architectural and urban research, this work addresses the complexity of contemporary public space, both in a conceptual and concrete sense.
Ljiljana Čavić, José Nuno Beirão
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Implementing open licensing in government open data initiatives: a review of Australian government practice [PDF]

, 2013
This paper finds that Australian Government agencies are embracing open access and a proactive disclosure culture, and that open licensing under Creative Commons licences is increasingly prevalent, but that shortcomings need to be addressed.
Anne Fitzgerald, Hooper, Neale, John S. Cook, Neale Hooper, Fitzgerald, Anne, Cook, John S.   +5 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Analysis of Public Green Open Space Management in Jambi City

Policy & Governance Review, 2020
The growth of the population requires space to accommodate human activities. The development aims to provide a space for humans, but it has an impact on the decreasing green open space.
Irsadunas Noveri, Khairun Najib, M. Yusuf   +2 more
doaj   +1 more source

Watch This Space! Designing for Children's Play in Public Open Spaces [PDF]

Geography Compass, 2008
Abstract This article reviews one important aspect of children's environments in urban areas: play in public open spaces. The focus is on the provision of spaces for play for children aged between about 4–11 years old. The article argues that children's play is important for their development and for society as a whole and the article
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Public Space and Security: Samsun/Batipark Sample

Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA
This study examines the perception of security in public spaces and the parameters that determine this perception in the context of open and green spaces.
Berna İzel GÜNGÖR, Tuğçe ŞANLI KATI   +1 more
doaj   +1 more source

New Urban Governance in Controlling Public Green Open Spaces in Indonesia [PDF]

E3S Web of Conferences
This study aims to describe how new urban governance controls public green open spaces in Indonesia. Cities in Indonesia experience an imbalance of public green open space that must be provided.
Sulistyaningsih Tri, Sunarto, Kulsum Umi
doaj   +1 more source