Results 41 to 50 of about 21,223,372 (296)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

A Category “Public Order” and Limitations on Party Autonomy in Contracts for the Carriage of Passengers by Sea

open access: yesLex Portus, 2021
This article attempts to research the purpose, the meaning and the essence of the category “public order” in the legal regulation and practice of law enforcement in the sphere of passengers’ sea shipping.
Minas Arakelian   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Optimization of social security patrol strategy based on graph theory and GGC algorithm

open access: yesDiscover Applied Sciences
To cope with complex dynamic patrol environments and maximize the benefits of regional social security patrols, this study abstracts patrol areas as a graph model and constructs a network diagram of the social security patrol area.
Jian Wang
doaj   +1 more source

Status of a Voivodship Governor as an Authority Responsible for the Matters of Security and Public Order

open access: yesBarometr Regionalny, 2019
The purpose of the article is to present the legal status of a voivodship governor in Poland within the area of security and public order. The representative of the Council of Ministers in a voivodship performs a managerial and coordination functions in
Jarosław Kostrubiec
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Bridging healthcare gaps through specialized mobile healthcare services to improve healthcare access and outcomes in rural Hungary

open access: yesScientific Reports
Telemedicine offers promising solutions to healthcare challenges in underserved rural areas. This study evaluates a public insurance-based telemedicine system implemented in Hungary, where 12 Mobile Healthcare Service Centers (MHSCs) provided general and
Mark Virag   +15 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Deep learning and social network-based forensic data mining and analysis for criminal investigations

open access: yesDiscover Applied Sciences
The fast growth of digital communication has made it more difficult to arrest those who breach the law. Criminals are increasingly working together behind the scenes on social media platforms to spread false information, perform criminal crimes, and ...
Fei Yan
doaj   +1 more source

Academic motivation and burnout among Chinese doctoral students: the mediating role of academic resilience and the moderating role of perceived stress

open access: yesFrontiers in Psychology
BackgroundAcademic burnout is a persistent concern in doctoral education, but the associations among doctoral students' motivation, resilience, stress, and burnout may depend on how motivational resources operate under demanding conditions.
Geng Zhao, Geng Zhao
doaj   +1 more source

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