Results 61 to 70 of about 7,686,922 (303)
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
War Risks in Shipping Contracts: The Impact of the Russo-Ukrainian Armed Conflict
Lex Portus, 2023 The article reviews certain issues of maritime contractual practice in the Russian-Ukrainian war context. Maritime supply chains have been heavily impacted by the devastating effect of hostilities which have shaped regional crisis practices for eighteen ...
Bohdan Fasii
doaj +1 more source
, 2015 The growing popularity of methodologies that turn "to the wild" for real world data creates new ethical issues for the HCI community. For investigations questioning interactions in public or transient spaces, crowd interaction, or natural behaviour ...
Festinger L., Fine G. A, Parker, Robbins
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Global public health training in the UK: preparing for the future.
, 2011 BACKGROUND: Many major public health issues today are not confined by national boundaries. However, the global public health workforce appears unprepared to confront the challenges posed by globalization.
Hall, Jennifer A +2 more
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Communicating the social sciences [PDF]
, 2008 This chapter reviews the sparse and somewhat scattered research literature that has specifically addressed the public communication of the social sciences (PCSS).
Cassidy, A
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Management of Public Drunkenness in Western Australia: Policing the Unpoliceable? [PDF]
Limina: A Journal of Historical and Cultural Studies, 2017 This paper examines the role of the criminal justice system in managing public order consequences from the problematic use of alcohol in Western Australia (WA) from its beginnings as a British colony in the 1830s up to the recent present.
Greg Swensen
doaj