Results 101 to 110 of about 13,409,369 (282)

The 4-Circles Tool 2.0—A Tool to Prepare Older Patients for Shared Decision Making: A Developmental and Feasibility Study

MDM Policy & Practice
Background: Shared decision making is an effective strategy for collaborative goal setting and action planning with older patients. However, many older patients feel unable to actively participate.
Stephanie von Helden-Lenzen, Maartje Feuler, Albine Moser, Jolanda Friesen-Storms, Ruth Dalemans, Emmylou Beekman   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Exploring the essential elements of meaningful public participation in next generation impact assessment: the Colombian context

The research explored the essential elements of meaningful public participation in next generation impact assessment (NGIA), in relation to the Colombian Environmental Impact Assessment (EIA) process.
Bayuelo Gonzalez, Mario Enrique
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Modernising Planning: Public Participation in the UK Planning System [PDF]

In the UK the formal land-use planning system is once more at a crossroads with the unprecedented levels of public comment on the recent Governmental Green Paper on Planning.
Alan Townsend, Janet Tully
core  

Making History Together: Public Participation in Museums

, 2020
The international online symposium brought together scholars, museum professionals and heritage practitioners to discuss how participatory history is constructed, developed, and implemented in museums.
Makoto, Goto, Konstantinou, Katerina, Redgate, Isabella, Boccalatte, Paola, Quoc-Tan, Tran, Trudel, Chantal, Ferloni, Julia, Chaudhur, Diviani, Dolgoy, Rebecca, Malone, Lucy, Povroznik, Nadezhda, Camarda, Antonella, CAUVIN, Thomas, Brosseau, Cédric, Yuta, Hashimoto, Akihiro, Kameda, Berta, Erika, Lemay-Perreault, Rébéca, Ayukawa, Carla, Maximova, Alisa, Everrett, Tom   +20 more
core   +1 more source

A new way of thinking? Exploring professionals’ perspectives on the sustainability of interprofessional team meetings: A focus group study

European Journal of General Practice
Background Interprofessional collaboration is essential to address the complex challenges in primary care. One widely used method for this purpose is interprofessional team meetings.
Jelena Slowig, Darcy Ummels, Emmylou Beekman, Marloes van Bokhoven, Albine Moser   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source