Results 81 to 90 of about 13,409,369 (282)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
BMC Health Services Research, 2018 Background Primary care nurses play a crucial role in setting personal goals and action plans together with chronically ill patients. This may be a challenge for practice nurses, who are often trained to adopt protocol-based work routines.
Stephanie Anna Lenzen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
e-Participation in Austria: Trends and Public Policies [PDF]
The paper is a first step to assess the status of e-participation within the political system in Austria. It takes a top-down perspective focusing on the policy framework related to citizens´ rights in the digital environment, the role of public ...
Georg Aichholzer, Doris Allhutter
core
People and NatureBackground. Fostering healthy urban living conditions is a critical public health objective. One efficient approach lies in the contact to nature, as numerous studies have shown that urban and peri‐urban natural elements both indoors and outdoors carry a
Marilisa Herchet +6 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Voluntary Participation in a Mechanism Implementing a Public Project [PDF]
In this study, a participation game in a mechanism to implement a public project is considered; in this game, agents decide simultaneously whether they will participate in the mechanism or not.
Shinohara, Ryusuke
core
An Evaluation of Public Participation in the Environmental Impact Assessment Process of the Maldives [PDF]
, 2015 Environmental Impact Assessment (EIA) is a proactive tool that assesses and addresses the environmental and social impacts of development projects. It has been identified as a process that can potentially deliver the goal of sustainable development ...
Zuhair, Mohamed Hamdhaan
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
BMC Public Health, 2017 Background The role of health communication in vaccination programmes cannot be overemphasized: it has contributed significantly to creating and sustaining demand for vaccination services and improving vaccination coverage.
Afiong Oku +13 more
doaj +1 more source