Results 91 to 100 of about 11,488,763 (293)

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu   +11 more
wiley   +1 more source

Integrating Environmental Sustainability into Public Procurement: Evidence from Ghanaian Local Government Entities [PDF]

open access: yesInternational Journal of Management, Accounting and Economics
Environmental sustainability is a growing concern for governments as they strive to promote responsible production and consumption within the public sector.
Amankwaa Asiedu
doaj   +1 more source

PUBLIC PROCUREMENT AS TOOL OF ENVIRONMENTAL POLICY [PDF]

open access: yes
Correlating private and social interests represents a continuous challenge for environmental policy. Traditional implementation tools proved to be not enough for accomplishing the objectives required by the protection of natural systems.
Ildiko IOAN, Florina BRAN
core  

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

open access: yesAdvanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang   +7 more
wiley   +1 more source

FINANCIAL CONTROL OF GOVERNMENT PROCUREMENT

open access: yesВестник Северо-Кавказского федерального университета, 2022
The article deals with the peculiarities of state financial control in the public procurement system of Russia. In connection with the changes observed in the public procurement system, the issue of their state financial control is important.
A. Sokolova, O. Chokhatarova
doaj  

Universal Battery Capacity Degradation Forecasting Driven by Foundation Models Across Diverse Chemistries and Conditions

open access: yesAdvanced Science, EarlyView.
A unified time‐series forecasting framework learns transferable battery capacity‐degradation patterns from 20 heterogeneous datasets spanning chemistries, formats, temperatures, and cycling conditions. A single model delivers competitive predictions on both known and previously unseen datasets, while physics‐guided representation learning improves ...
Joey Chan   +8 more
wiley   +1 more source

Public procurement in the Czech Republic: Focused on regional development and e-procurement

open access: yes, 2014
Relations between public procurement, regional development, and e-procurement are discussed in this chapter. First, main themes of the debate are reviewed.
Machů, Jiří   +2 more
core   +1 more source

Corruption risk factors: an analysis of public procurement in Nigeria [PDF]

open access: yes
Nigeria has consistently ranked 6th amongst oil-producing nations of the world but despite the enormous revenues from the sale of petroleum resources in the past five decades, the country has made little advance in terms of infrastructure, quality of ...
Ekwo, Grace
core  

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

open access: yesAdvanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao   +19 more
wiley   +1 more source

Auction versus Negotiation in Public Procurement: Looking for Empirical Evidence [PDF]

open access: yes
The relative efficiency of auctions and negotiations is still a puzzle in the literature. While auctions are the prescribed procedures and the most used ones for public procurement, in the private sector, where buyers are free to choose their purchasing ...
Anne Yvrande-Billon   +2 more
core  

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