Results 41 to 50 of about 14,119,859 (294)

The Clear and Present Danger Test in Turkish Penal Law

Ceza Hukuku ve Kriminoloji Dergisi, 2023
The concept of clear and present danger originates from American law has become a phenomenon in different legal systems, particularly in connection with freedom of expression.
Büşra Demiral Bakırman
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Study on Exterior Wall Tile Degradation Conditions of High-rise Buildings in Taoyuan City

Journal of Asian Architecture and Building Engineering, 2018
In recent years in Taiwan, pedestrians have been injured by external wall tiles falling from high-rise buildings. In numerous cases, exposure to temperature and/or seismic behavior caused the tiles to fall off.
Chu-Tsen Liao
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Protect Your Sky: A Survey of Counter Unmanned Aerial Vehicle Systems

IEEE Access, 2020
Recognizing the various and broad range of applications of unmanned aerial vehicles (UAVs) and unmanned aircraft systems (UAS) for personal, public and military applications, recent un-intentional malfunctions of uncontrollable UAVs or intentional ...
Honggu Kang, Jingon Joung, Jinyoung Kim, Joonhyuk Kang, Yong Soo Cho   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Presumption of Innocence and Public Safety: A Possible Dialogue

Stability : International Journal of Security and Development, 2014
In Mexico, increasing demands for public safety coupled with the need for a more effective criminal justice system resulted in the security and justice constitutional reform of 2008. The outcome was a constitutional framework with provisions based on the
Ana Aguilar-Garcia
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Masking by health care and public safety workers in non‐patient care areas to mitigate SARS‐CoV‐2 infection: A systematic review

Journal of the American College of Emergency Physicians Open, 2022
Objectives Wearing a mask is an important method for reducing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission in health care and public safety settings.
P. Daniel Patterson, Quentin S. Mcilvaine, Lily Nong, Mary K. Liszka, Rebekah S. Miller, Francis X. Guyette, Christian Martin‐Gill   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source