Results 31 to 40 of about 314,050 (316)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Mental illness in the prison system: a perspective from the prison technical committee of Tamaulipas, Mexico

Revista de Psicología y Ciencias del Comportamiento de la Unidad Académica de Ciencias Jurídicas y Sociales, 2023
The prevalence of mental disorders in prisons is a growing phenomenon involving various social actors, the health of persons deprived of liberty and the functioning of penitentiary institutions.
José Luis Carpio-Domínguez, Ignacio Hernández-Rodríguez, María Guadalupe Montoya-Coello   +2 more
doaj   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Making Security Interests Public [PDF]

, 2012
Movable assets tangible or intangible often account for most of firm's capital stock. Thus it is important for jurisdictions to develop adequate laws on secured transactions to allow borrowers and lenders to recognize movable assets as collateral, supporting financing secured with such assets.
Downes, Santiago Croci, Hennig, Betina Tirelli, Alvarez de la Campa, Alejandro   +2 more
openaire   +3 more sources

A Neural Relation Extraction Model for Distant Supervision in Counter-Terrorism Scenario

IEEE Access, 2020
Natural language processing (NLP) is the best solution to extensive, unstructured, complex, and diverse network big data for counter-terrorism. Through the text analysis, it is the basis and the most critical step to quickly extract the relationship ...
Jiaqi Hou, Xin Li, Rongchen Zhu, Chongqiang Zhu, Zeyu Wei, Chao Zhang   +5 more
doaj   +1 more source

Exploring Text Mining and Analytics for Applications in Public Security: an in-depth dive into a systematic literature review

Socioeconomic Analytics, 2023
Text mining and related analytics emerge as a technological approach to support human activities in extracting useful knowledge through texts in several formats.
Victor Diogho Heuer de Carvalho, Ana Paula Cabral Seixas Costa   +1 more
doaj   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Lightweight deep learning model for crime pattern recognition based on transformer with simulated annealing sparsity and CNN

Scientific Reports
This study addresses the pressing need for high efficiency and low resource consumption in crime pattern recognition within public safety governance by proposing a lightweight deep learning model known as the lightweight crime recognition network (LCRNet)
HongYuan Lu, ChengXin Chen, YuQi Ma, YanMing Ma   +3 more
doaj   +1 more source