Results 91 to 100 of about 239,322 (282)

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

open access: yesAdvanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han   +10 more
wiley   +1 more source

Nuevos caminos con buenos maestros en Traducción e Interpretación. En homenaje a Valentín García Yebra

open access: yesMutatis Mutandis, 2011
La presente contribución es el resultado de una vivencia personal y profesional compleja, en la que una formación básica de filóloga alterna con una práctica profesional de la traducción, de catedrática de traducción e interpretación, y finalmente de ...
Carmen Valero Garcés
doaj  

The Distributed Ontology Language (DOL): Use Cases, Syntax, and Extensibility [PDF]

open access: yes, 2012
The Distributed Ontology Language (DOL) is currently being standardized within the OntoIOp (Ontology Integration and Interoperability) activity of ISO/TC 37/SC 3.
Galinski, Christian   +5 more
core   +2 more sources

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang   +16 more
wiley   +1 more source

Wikis en lenguas para fines específicos y su traducción

open access: yesRed U, 2011
RESUMENLas herramientas Wiki pueden llegar a ser muy útiles tanto en la enseñanza de lenguas en general como en la traducción, sobre todo si se tiene en cuenta que, hoy en día, dentro del nuevo marco del ...
Raquel Lázaro Gutiérrez   +2 more
doaj  

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy   +8 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Serving Limited English Proficient Clients [PDF]

open access: yes, 2014
When serving walk-ins, the goal is to provide the same services, information and referrals as we would provide to the English-speaking public. This is true whether the walk-in ultimately turns out to be eligible for our services or not.
Neighborhood Legal Services, Inc.
core   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

open access: yesAdvanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang   +3 more
wiley   +1 more source

Public service interpreting and translation in Spain and the COVID-19 pandemic

open access: yes
The COVID-19 outbreak that started in 2020 constituted a health, socioeconomic, and political crisis. At the same time, it led to a paradigm change in several areas, including communication and interpersonal relationships. The measures enforced to prevent the spread of the virus, along with the need for information given the novelty of the situation ...
Vitalaru, Bianca   +1 more
openaire   +1 more source

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