Results 131 to 140 of about 2,130,699 (296)

Consular conundrum: the rising demands and diminishing means for assisting Australians overseas [PDF]

open access: yes
Australians are travelling more than ever. In 2012, they took more than eight million trips overseas, more than double the number a decade ago.  Public expectations of the assistance government can provide when travellers encounter trouble are ...
Alex Oliver
core  

The Internet as a Service Channel in the Public Sector : A substitute or complement of traditional service channels? [PDF]

open access: yes, 2006
The Internet has been used as a channel for public service delivery since the mid 1990’s. During the first years of its existence it was believed to be the service channel of the future, making all other channels obsolete.
Deursen, Alexander van   +1 more
core   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

open access: yesAdvanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang   +11 more
wiley   +1 more source

The Transformation of Public TV Companies into Digital Services at the BBC and RTVE [PDF]

open access: yes, 2012
Some authors question the existence of public television companies in the new environment of digitalization, Internet proliferation, growing competition and audience segmentation.
Medina, M. (Mercedes)   +1 more
core  

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu   +6 more
wiley   +1 more source

Public service media and exposure diversity: introduction

open access: yesInternational Journal of Communication : IJoC, 2015
Exposure diversity is a relatively new and as yet to be explicitly formulated objective of contemporary media policy. While it holds certain potential—in particular in the messy digital space characterized by abundance and exponentially increased user choices—it comes with certain risks too.
Helberger, N., Buri, M.
openaire   +2 more sources

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu   +14 more
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

open access: yesAdvanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li   +12 more
wiley   +1 more source

Public Service Media and Challenge of Crossing Borders: Assessing New Models

open access: yesMedijske Studije, 2015
This article addresses the need for new models of public service media. First, the article looks at the core factors, or borders, that frame the quest for new models: the digitalization, deinstitutionalization, and globalization of communication. It then
Minna Aslama Horowitz
doaj  

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

open access: yesAdvanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang   +10 more
wiley   +1 more source

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