Results 71 to 80 of about 1,619,727 (310)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Firms and public service provision in Russia [PDF]

This paper reports first results from a survey of 404 middle-sized and large manufacturing firms from 40 Russian regions in April-June 2003. We examine the extent of social service and infrastructure provision by the firms and the firms’ assessment of ...
Ekaterina Zhuravskaya, Jukka Pirttilä, Laura Solanko, Olga Lazareva, Pertti Haaparanta, Tuuli Juurikkala   +5 more
core   +3 more sources

Managing contextual information in semantically-driven temporal information systems [PDF]

, 2011
Context-aware (CA) systems have demonstrated the provision of a robust solution for personalized information delivery in the current content-rich and dynamic information age we live in.
Isiaq, SO, Osman, T, Peytchev, E
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Strengthening keratoconus management systems in South African public sector facilities

African Vision and Eye Health
Background: Provision of comprehensive eye care remains a challenge in low to medium income countries including South Africa. The recent surge of keratoconus (KC) is exacerbating this challenge especially in terms of the need for specialised equipment ...
Pheagane M.W. Nkoana, Khathutshelo P. Mashige, Vanessa R. Moodley   +2 more
doaj   +1 more source

DEVELOPMENT OF PROVIDING PUBLIC SERVICES IN THE ECONOMY AS A GUARANTEE OF EFFICIENCY IN EUROPEAN INTEGRATION PROCESSES

Baltic Journal of Economic Studies, 2019
The transitional period, in which most of European and the world countries today are, is in need of renewal and continuity of integration processes in vital areas to which the economic sphere itself belongs.
Natalija Berlach, Galina Striiashko
doaj   +1 more source

Fiscal Federalism and Public Service Provision in Canada [PDF]

This paper provides a general overview of the allocation of revenues and expenditures across levels of governments in Canada and discusses how public services in specific areas are financed and delivered.
Jean-François Tremblay
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

PUBLIC WAGE BILL, DEBT CONSTRAINTS, AND SERVICE DELIVERY COMPETITION FOR LIMITED PUBLIC FUNDS: SOUTH AFRICAN GOVERNMENT

Innovative Issues and Approaches in Social Sciences
The National Treasury, together with the Provincial Treasurers, are the custodians of public finances and they are responsible for budgeting for the national and provincial government departments.
Xolani Thusi, Nokukhanya N. Jili
doaj   +1 more source

Pengaruh Pelebaran Jalan terhadap Pemanfaatan Ruang Koridor Jalan Mertoyudan Kabupaten Magelang

Jurnal Pembangunan Wilayah dan Kota, 2015
With the position of the Panakukang Mas region as a center integrated settlement services, can create a basic urban problems that limited the availability of public facilities and qualified in accordance with the dynamic needs of the community with the ...
Muhamad Mustanir
doaj   +1 more source