Results 61 to 70 of about 15,873,374 (305)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The welfare state driving “me” and “we” medicine – a critical discourse analysis

New Genetics and Society, 2020
This study explored the relationship between visions of personalized medicine, for-profit companies, and state governance in the context of an ongoing discussion of “me” vs. “we” medicine.
Morten Deleuran Terkildsen, Viola Burau, Ulla Væggemose, Nina Konstantin Nissen   +3 more
doaj   +1 more source

Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada

Human Vaccines & Immunotherapeutics, 2022
Between 18 Dec 2017 and 27 June 2018, a mumps outbreak occurred in two Canadian Indigenous communities. An outbreak dose of mumps-containing vaccine was offered as part of control measures.
Wallis Rudnick, Sarah Wilson, Jo Ann Majerovich, Michelle Haavaldsrud, Marene Gatali, Cai-Lei Matsumoto, Shelley Deeks   +6 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Other title: State of Connecticut Department of Emergency Services and Public Protection; Other title: Emergency Services and Public Protection

, 2017
Updated irregularly; Began in 2012.; Title from home page (publisher's Web site, viewed Feb. 9, 2012).; At head of title: State of Connecticut.; Harvested from the web on 5/8/17Official website of the Connecticut Department of Emergency Services and ...

core   +1 more source

Psychological experiences of syndactyly among youth aged 12–30: exploring mental health challenges and coping mechanisms in Islamabad – a qualitative study

BMJ Open
Objective To explore the psychological and social experiences of youth aged 12–30 years living with congenital syndactyly in Islamabad.Design A qualitative phenomenological design was employed. Semi-structured, in-depth interviews were conducted.Settings
Muhammad Jawad, Babar Tasneem Shaikh, Khansa Muhammad Sarwar, Shaheer Ellahi Khan, Zareef Uddin Khan, Syeda Hina Shah, Khola Raashid, Aqsa Elahi   +7 more
doaj   +1 more source

Marketing of Public Services

Economic Analysis, 2018
Public services are provided by government and have been traditionally supply-oriented. Changing citizen expectations put pressure on government agencies and public sector organizations to be accountable for efficiency and effectiveness.
Madhavi Ayyagari, Sanjai Parahoo, Heather Lea Harvey   +2 more
doaj   +1 more source

Process evaluation of a programme to empower community nurse leadership

BMC Nursing, 2021
Background The Nurses in the Lead (NitL) programme consists of a systematic approach and training to 1) empower community nurses in implementing evidence, targeted at encouraging functional activities of older adults, and 2) train community nurses in ...
Ruth G. M. Vogel, Gerrie J. J. W. Bours, Teuni H. Rooijackers, Silke F. Metzelthin, Petra M. G. Erkens, Erik van Rossum, Sandra M. G. Zwakhalen   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Development of flow cytometric opsonophagocytosis and antibody-mediated complement deposition assays for non-typeable Haemophilus influenzae

BMC Microbiology, 2018
Background Haemophilus influenzae is found in the nasopharynx of 80% of the human population. While colonisation with non-typeable Haemophilus influenzae (NTHi) is usually asymptomatic, it is capable of causing acute and chronic otitis media (OM) in ...
Stephen R. Thomas, Stephanie Leung, Katy Knox, Tom M. A. Wilkinson, Karl J. Staples, Pascal Lestrate, Dominique Wauters, Andrew Gorringe, Stephen C. Taylor   +8 more
doaj   +1 more source