Results 41 to 50 of about 822,293 (303)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2021 This film was made to accompany the simultaneously published report on Queering Public Space, which I authored with Ammar Azzouz. It provides an accessible educational resource to convey the main arguments of the report.
Zebracki, Martin +7 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Public Space in Planning Traditions [PDF]
برنامهریزی توسعه شهری و منطقهایPublic spaces have important role in city life, are so effective for cities for appropriate quality of life and economic, social and cultural development.
Hesam Hassanipour +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cognitive dimensions of public space
Filozofia Publiczna i Edukacja Demokratyczna, 2016 The paper presents a new approach to cognitive aspects of public space based on the Bayesian framework for cognition. According to it, cognition is powered by hypothesis-testing brain, constantly minimizing its prediction error.
Maciej Błaszak
doaj +1 more source
Visibility and the Policing of Public Space
, 2011 From studies of ‘panoptic’ CCTV surveillance to accounts of undercover police officers, it is often mooted that visibility and invisibility are central to the policing of public space.
Laing, Mary, Cook, Ian
core +1 more source
, 2021 With the rapid development of society, the urban environment is facing great challenges. It is necessary to carry out public artworks design in urban public spaces.
Zainal Abidin, Sazrinee +2 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source