Results 31 to 40 of about 191,808 (298)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Identification Of Ecotherapy Design Criteria In Public Open Spaces As An Effort To Improve Visitor’s Mental Health

Journey, 2023
All activities that occur in public open spaces are basically forms of human expression as social beings who always have a deep relationship with the environment in meeting physical, psychological and social needs.
Km. Deddy Endra Prasandya, Made Wina Satria, Made Arya Adiartha   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Public Spaces: Socioeconomic Challenges

Land
This Special Issue, entitled ‘Public Spaces: Socioeconomic Challenges’ considers the concept of general well-being from the point of view of collective achievements and/or external conditions that can favorably impact the individual when implemented ...
Teresa de Noronha
doaj   +1 more source

Propreté et malpropreté des espaces privés et publics urbains au Liban

Projets de Paysage, 2012
In Lebanon, the problem of hygiene does not arise at the private property level because every inhabitant, according to agreed social rules, takes naturally the adequate measures in order to assure the cleanliness of his/her house.
Nada Chbat
doaj   +1 more source

Co-Designing Spaces for Public Service

Designs, 2022
Services of public interest concern the design of spaces and services in their most systemic and transformative conception, offering access to the essential functions of everyday life, and developing open solutions for a social collective understood as a
Luisa Collina, Laura Galluzzo, Ambra Borin, Claudia Mastrantoni   +3 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Les rives lacustres comme espaces publics : essai de cartographie. L’exemple du lac d’Annecy

M@ppemonde, 2018
As outdoor activities develop, public spaces are transformed and extend beyond cities, blurring the limits between public and private spaces. This paper relies on a case study of Lake Annecy (Haute-Savoie, France) and analyzes public space at the ...
Alice Nikolli
doaj   +1 more source

A new perception; generating well-being urban public spaces after the era of pandemics

Developments in the Built Environment, 2022
In the new pandemic era, the perception of urban spaces has been developed and the definition of well-being in urban public settings is ambiguous. The essay helps with theorizing the construction of urban public spaces and the health spaces influenced by
Samah El Khateeb, Indjy M. Shawket
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source