Results 51 to 60 of about 176,669 (260)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Quality Improvement of Urban Public Space from the Perspective of the Flâneur
LandAs the quality of public space has become significant for urban development, the creation of high-quality public spaces is becoming increasingly important. Since the implementation of urban renewal policies, an increasing number of buildings have emerged,
Li Wang +3 more
doaj +1 more source
Sense of place attachment of user in public open space commercial building in West Jakarta [PDF]
BIO Web of ConferencesThe existence of public spaces dates back to Ancient Roman, Greek, and the present day. Although people today are known for their individualistic attitudes, they still need a place to communicate. However, public space is present everywhere possible, one
Anggiani M., D Ayudya R., Hirda A.
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Bulletin of Geography. Socio-Economic Series, 2019 Centrally located public spaces, such as old towns, are an important feature of historic towns. They are often the most characteristic and representative element of a town that brings together members of the local community, plays various sociological ...
Szczepańska Agnieszka +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Factors related with public open space use among adolescents: a study using GPS and accelerometers
International Journal of Health Geographics, 2018 Background Low physical activity levels and high levels of sedentary time among adolescents call for population wide interventions. Public open spaces can be important locations for adolescents’ physical activity.
Linde Van Hecke +7 more
doaj +1 more source